The role and mechanism of action of menthol in topical analgesic products

Authors: J. V. Pergolizzi Jr., MD; R. Taylor Jr., PhD; J.-A. LeQuang ,BA; R. B. Raffa, PhD, and for the NEMA Research Group First published: 10 March 2018 Summary What is known, and objective Menthol has been used as a non-opioid pain reliever since ancient times. A modern understanding of its molecular mechanism of action could form the basis for generating …

When it comes to Tendonitis, Inflammation Deserves a Second Thought

Back in the 1990s there was a major shift in thinking regarding chronic tendinopathies. Histologic data pointed to a lack of acute inflammatory cells in the load-bearing regions of tendons, and some studies noted collagen separation and thinning without inflammatory cell infiltrates1,2,3,4. As the thinking changed to ‘chronic tendinopathies are caused by an unknown degenerative process without inflammation,’ treatment strategies …

Dr. Stuart Tomares

Doctor of Medicine, Founder and CEO of übertherm LLC

Pain Specialists Awareness of Topical Analgesics and Their Use in Pain Control

Joseph V. Pergolizzi1,2*, Robert B. Raffa3, Robert Taylor4, Charles Fleischer4, Gianpietro Zampogna4, Lynn Nopper5, Frank DiLorenzo5, Clay M. Duval4, Alana N. Edun4, Jasmine Salamara5 1Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA 2Department of Pharmacology, Temple University School of Medicine, Philadelphia, PA, USA 3Department of Pharmaceutical Sciences, Temple University School of Pharmacy, Philadelphia, PA, USA 4NEMA …

Efficacy of IASTM for the Treatment of Musculotendinous Injuries

Graston Technique® therapy raises the bar again! Graston Technique® therapy is an evidence-based method of instrument-assisted soft tissue mobilization (IASTM) combined with exercise to improve musculoskeletal function. There are various levels of evidence that support its efficacy for a wide variety of conditions. In 2016, the first systematic review examining the efficacy of IASTM reported “some evidence supporting its ability …

The Future of Muscle Function Testing

The kiio Sensor accurately measures, stores, and wirelessly communicates force over time during any exercise. On-board sensors, a CPU, and special electronics calculate actual force, power, exercise pacing, and more. The kiio Sensor is integrated with kiio FLEX software to offer a comprehensive solution for assessing, training, monitoring, and improving the overall performance of patients and athletes. With 50 samples …

Marc Sherry

Marc Sherry

Physical Therapist and Athletic Trainer

Why Focus on the Thoracic Spine?

Everyone is big into core stability and core programming. The lumbar spine with low back pain is also obviously a huge issue in our society today. When we look at the lumbar spine, we have these big buzz words—core stability, the core. When we start to look at all of the things that attach to the lumbar spine, it’s important …

Sue Falsone PT

Sue Falsone

PT, MS, SCS, ATC, CSCS, COMT, first female head athletic trainer in any of the four major sports in the US

Oxygenated glycerol triesters (OGTs) and menthol shown to provide better pain relief than mentholated cream alone

In light of concern regarding OTC pain relievers, topical analgesics present an important option for the treatment of acute and chronic pain. Pain is one of the most undertreated healthcare problems in the world. It is also among the most common reasons for patients to seeking health care. When it comes to treating pain, the goals depend on the nature …

Exacerbation of Inflammation by Aggressive Cold Therapy: Preventing Microcellular Ice Crystal Injury

Exacerbation of Inflammation by Aggressive Cold Therapy: Preventing Microcellular Ice Crystal Injury. An Alternative to Conventional R.I.C.E. Therapy Stuart Tomares, M.D. Abstract Exposure to sub-0°C temperatures has long been known to cause mammalian tissue damage and cell death (frostbite). The biological mechanisms of such injury were elucidated in the 1970s and 1980s in research into the viability of cold storage …

Dr. Stuart Tomares

Doctor of Medicine, Founder and CEO of übertherm LLC

Arachnoiditis: Incurable, Disabling, Controversial and Heading Your Way

Misunderstood and underreported, arachnoiditis is a neuropathic malady that affects the arachnoid layer of the meninges. It can result from routine medical procedures and can leave patients permanently incapacitated. A more severe type of arachnoiditis is adhesive arachnoiditis. Adhesive arachnoiditis results in scarring and adhesions within the meninges. Additionally, it compresses the nerve rootlets within the thecal sac and can …

New Product Alert – übertherm Cold Compression Wraps

A new product – übertherm cold wraps, with Ice Pillow™ Technology – deliver cold therapy in a way that significantly improves its effectiveness and, ultimately, the outcome for the patient. Continue reading and learn about how traditional cold therapy can worsen inflammation, how übertherm’s innovative technology is solving this problem, and how it can benefit both your clinic and your patients. …

Dr. Stuart Tomares

Doctor of Medicine, Founder and CEO of übertherm LLC